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Austria, Czech Republic, France, Germany, Italy, Poland, Spain, Switzerland, Turkey and Great Britain
+ 800 624 367 23
+ 800 MAGFORCE
United States, Canada, Guam, Puerto Rico and US Virgin Islands
+ 1 844 833 9623
Phone numbers for other countries
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„I am relieved and indescribably happy that I am doing well.“

M. Dobrowolski, Patient

„I am relieved and indescribably happy that I am doing well.“

M. Dobrowolski, Patient

The NanoTherm® therapy in detail

At the discretion of the attending neurosurgeon, the NanoTherm® liquid containing the magnetic nanoparticles is specifically injected into the tumor or applied at the resection cavity wall in the course of the tumor resection.
The particles, which contain iron oxide, are then activated during six one-hour sessions in the NanoActivator® by an externally applied, rapidly alternating magnetic field, which generates heat. This either destroys the tumour cells or sensitizes them to additional treatment approaches such as radiotherapy and/or chemotherapy. The effectiveness of these additional therapies is significantly improved while at the same time, the surrounding tissue is spared.
rapidly alternating magnetic field, which generates heat. This either destroys the tumor cells or sensitizes them to additional treatment approaches such as radiotherapy and/or chemotherapy. The effectiveness of these additional therapies is significantly improved while at the same time, the surrounding tissue is spared.

Course of treatment

Prior to NanoTherm® treatment, it must be determined whether metal-containing objects in the body may need to be removed within 40 cm of the tumor (metallic fillings, artificial joints, screws, etc.). If these are not removed, they would heat up during therapy. The attending physician will discuss any further steps with the patient. The tumor treatment with NanoTherm® is broken down into three steps:

1.
Analysis of the tumor

First, the tumor is measured using an imaging method, e.g. computer tomography, MRT or PET. Thus, the dose and position for the injection of the nanoparticles can be optimally planned.

2.
Instillation of nanoparticles into the tumor

The physician instils or applies the NanoTherm® liquid precisely at the desired location. S/he also establishes access in the form of a catheter for direct temperature measurement and monitoring in the treatment area during the first NanoActivator® session.

3.
Several treatment sessions in the alternating magnetic field

The NanoActivator® is a specially developed medical device, which generates the alternating magnetic field that activates the nanoparticles, and thus generates the desired temperatures. The patient completes six one-hour sessions over a period of three weeks, gladly accompanied by a companion.

Treatment results

Since 2011, MagForce AG holds the European CE certificate (“European Certification”) and thus official approval of NanoTherm® therapy for the treatment of brain tumors in Germany and all member states of the European Union. The effectiveness of NanoTherm® therapy has already been clinically tested on approximately 90 brain tumor patients and in pilot studies on approximately 80 patients with, inter alia, pancreatic, prostate, breast and oesophageal cancer.

A patient’s experiences

Since receiving official approval in 2011, brain tumor patients have been successfully treated using NanoTherm® therapy. One of them reports on his experiences here.

Mateusz Dobrowolski
brain tumor patient

Mateusz Dobrowolski, who is from Poland, received the diagnosis of a brain tumor before he was 30 years old. This was followed by surgery and additional treatment attempts. In 2016 he was treated in Berlin using NanoTherm® therapy with overwhelming success. One and a half years later, he returned for a follow-up visit and met with MagForce for an interview to talk about his personal experiences with the treatment

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NanoActivator® Treatment Centers

The NanoActivator® is available at the following locations and the medical personnel has been trained accordingly so that successful treatment using NanoTherm® therapy is possible.

Contact treatment centres

For more information concerning the treatment centres, please contact us using the toll-free number: 0800 - 66 46 46 1 (outside Germany: +49 30 - 30 83 80 - 73)
or send us an email:

Frequently asked questions

After a confirmed tumor diagnosis and the introduction of the ferrofluid containing the nanoparticles, NanoTherm®, the actual therapy application for the patient consists of six one-hour sessions on the NanoActivator®. This causes the particles containing iron oxide to warm up through the targeted alternation of the magnetic field, which achieves the desired therapeutic effect. As a rule, these sessions occur twice a week during a three-week period.

Please note that it may still be necessary to remove metallic objects near the tumor (e.g. dental fillings, crowns, implants, artificial joints) or replace them with alternatives made of plastic prior to the treatment. The reason for this: All metals within a radius of 40 centimetres around the tumor can also heat up in the alternating magnetic field.
Patients with non-removable medical implants such as pacemakers, neurostimulators or dosage pumps cannot benefit from NanoTherm® therapy due to possible interference with the magnetic field of the NanoActivator®.

Generally, a session in the alternating magnetic field is nearly completely free of pain and discomfort. The NanoActivator® does not cause claustrophobia such as a computer tomography (CT) or an MRI. Instead, the patient lies comfortably on a bed, which is adjusted to their individual comfort.

In the past, the following side effects have been reported in varying degrees during treatment.

Frequent [1 to 10 people out of 100]

The primary side effects observed during and/or after treatment using the NanoActivator® were sweating, a general sensation of heat and a slight increase in body temperature up 38 °C in the treatment area, accelerated pulse rate [tachycardia], headache or high blood pressure.

Rare [1 to 10 people out of 10,000]

Seizures and motor disturbances have been observed in some patients during treatment, but in most cases they were not their first occurrence, as they had also been observed prior to treatment. In addition, an increase in body temperature to over 38 °C and a lowering of blood pressure [hypotension] were observed in a small number of patients.

No hypersensitivity or allergic reactions were detected in previous clinical studies.

The NanoTherm® therapy components, NanoPlan® and NanoActivator®, are certified with the CE symbol as a medical product for the treatment of brain tumors throughout the EU.

NanoTherm® therapy is available to patients from Germany and patients from abroad at selected hospitals in Germany. The opening of the first treatment centre in Lublin, Poland, is being prepared. Additional treatment centres in Italy and other European countries are to follow.

For all further information, please contact the patient information department at the toll-free number, 0800 – 66 46 46 1 [outside of Germany: +49 30 – 30 83 80 – 73] or consult your physician. Please feel free to contact us at the following email address: patient-info@magforce.com.

Naturally all inquiries are strictly confidential and are subject to medical confidentiality.